Fig. 2.

H-apoD Tg mice are more resistant to KA-induced seizures. a Seizure index was evaluated for 2 h, according to the following arbitrary scale [95]: 0, no seizure; 1, one severe seizure (class 4–5); 2, three to five severe seizures; 3, six to ten severe seizures; and 4, more than ten severe seizures or very severe (class 6) seizures, in WT and H-apoD Tg mice injected with kainic acid (15 mg/kg). Cumulative seizure score was assessed as the sum of the scores recorded each 5 min over a 2-h period after KA injection in WT and H-apoD Tg mice. Mann–Whitney U test: *p < 0.05; ***p < 0.001 compared with WT. b The latency to ‘stage 2’, ‘stage 3’ and ‘stage 4’ seizures was measured in WT (grey bars) and H-apoD Tg (dark grey bars) mice. Animals that did not present these ‘stage’ seizures were given a value of 120 min. Two-way ANOVA followed by Bonferroni post-test: *p < 0.05; ***p < 0.001 compared with WT. Values are means ± SEM of 17 animals per group