Fig. 2.

Secondary chemical shifts for ¹H^α, 13C^α, 13C^β and 13C′ resonances versus residue numbers. The random coil chemical shift values were obtained from BMRB database (http://www.bmrb.wisc.edu/published/Ikura_cs_study/index.html). The secondary structural elements of the N-terminal domain in the crystal structure of full length M^pro (PDB code: 2H2Z) (Xue et al. 2007) are indicated on the top of graph. The solid and hollow boxes stand for α-helices and β-strands, respectively