Table 3.

Physicochemical properties from AVPpred

#	AAindex ID	Description	Polarity	Reference
1	BEGF750103	Conformational parameter of beta-turn	✔	[18]
2	BULH740102	Apparent partial specific volume		[19]
3	CHAM810101	Steric parameter	✔	[20]
4	CHOP780204	Normalized frequency of N-terminal helix	✔	[21]
5	CHOP780206	Normalized frequency of N-terminal non helical region	✔	[21]
6	CHOP780215	Frequency of the 4th residue in turn	✔	[21]
7	CIDH920104	Normalized hydrophobicity scales for alpha/beta-proteins	✔	[21]
8	COHE430101	Partial specific volume		[22]
9	FASG760105	PK-C	✔	[23]
10	FAUJ880104	STERIMOL length of the side chain		[24]
11	FINA770101	Helix-coil equilibrium constant	✔	[25]
12	FINA910101	Helix initiation parameter at position i − 1		[26]
13	GEIM800101	Alpha-helix indices	✔	[27]
14	GEIM800102	Alpha-helix indices for alpha-proteins	✔	[27]
15	GEIM800104	Alpha-helix indices for alpha/beta-proteins	✔	[27]
16	KARP850101	Flexibility parameter for no rigid neighbors	✔	[28]
17	KARP850102	Flexibility parameter for one rigid neighbor	✔	[28]
18	AURR980101	Normalized positional residue frequency at helix termini N4′	✔	[29]
19	AURR980118	Normalized positional residue frequency at helix termini C”	✔	[29]
20	AURR980120	Normalized positional residue frequency at helix termini C4′	✔	[29]
21	AVBF000107	Slopes tripeptide FDPB PARSE neutral		[30]
22	GEOR030102	Linker propensity from 1-linker dataset		[31]
23	KIDA850101	Hydrophobicity-related index	✔	[32]
24	GUYH850102	Apparent partition energies calculated from Wertz-Scheraga index	✔	[33]
25	CASG920101	Hydrophobicity scale from native protein structures	✔	[34]

Selected physicochemical properties to build the AVPpred algorithm by Kumar [2]. AAindex amino acid index database [3]. Polarity (✔) physicochemical properties are directly or indirectly related to the polarity