Fig. 1.

SGTA structural information. a The human SGTA gene is located on chromosome 19p13.3. The gene is organized into 12 exons, encoding a 313-amino-acid protein. Schematic of the SGTA protein delineating the interaction site (if known) of its established client proteins. Adapted from Buchanan et al. [8]. b TPR-containing chaperone proteins known to associate with steroid receptors. Sourced from Protein Knowledge Base (UniProtKB). c Schematic diagram of the alternative isoform of SGTA, SGTB, which has approximately 60 % amino acid sequence identity to SGTA. Shaded boxes represent TPR domains; Q glutamine-rich domain, PPIase peptidylprolyl isomerase, U-box E3 ubiquitin ligase, J domain DnaJ homologous J domain