Figure 2. Neuroimaging Pattern of the Significant Differences Between Participants With vs Without Sleep-Disordered Breathing in Amyloid Deposition, Gray Matter Volume, Perfusion, and Glucose Metabolism.

Results of the voxelwise analyses of covariance exhibiting between-group differences in amyloid deposition (A), gray matter (GM) volume (B), perfusion (C), and glucose metabolism (D), using magnetic resonance imaging and partial volume effects–corrected positron emission tomography data. Analyses were adjusted for age, sex, education, body mass index, sleep medication use, and APOE4 status. Results were obtained at a P < .005 (uncorrected) threshold, and only clusters surviving a familywise error–cluster-level correction are reported. APOE indicates apolipoprotein E; SDB−, negative for sleep-disordered breathing; SDB+, positive for sleep-disordered breathing.