Table 2. Results of Forward Stepwise Regressions Showing the Variables Most Strongly Associated With SDB-Associated Brain Changes.
| Factor | Unstandardized coefficient (95% CI) | Standardized coefficient | R2 | P value |
|---|---|---|---|---|
| Amyloid burden | ||||
| Step 1 | ||||
| Intercept | 0.88 (0.85-0.91) | NA | NA | <.001 |
| Hypoxia composite | 0.06 (0.02-0.10) | 0.28 | 0.08 | .002 |
| Step 2 | ||||
| Intercept | 0.86 (0.82-0.90) | NA | NA | <.001 |
| Hypoxia composite | 0.06 (0.02-0.10) | 0.26 | NA | .004 |
| APOE4 status | 0.07 (0.001-0.14) | 0.18 | 0.11 | .05 |
| Full model | NA | NA | 0.16 | .02 |
| Gray matter volume | ||||
| Step 1 | ||||
| Intercept | 0.77 (0.76-0.78) | NA | NA | <.001 |
| Apnea-hypopnea index | 0.01 (5.718 × 10−4-0.02) | 0.19 | 0.04 | .04 |
| Full model | NA | NA | 0.11 | .20 |
Abbreviations: APOE4, apolipoprotein E; NA, not applicable.