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Time to clotting (R-time) of rFIX-treated and buffer-treated FIX ko mice. Median R-time in buffer-treated animals was 98.7 min. Treatment with 75 IU/kg of BAX326 led to a statistically significant reduction of time to clotting (54.5 min; P = 0.00074). Median R-time was similarly reduced to 56.2 min by treatment with 75 IU/kg of the active control item, a previously licensed rFIX
