Figure 5.

Example PDE simulations of diverse GTPase regulatory phenotypes from a single parameter set in a 2D domain. Top panels: steady-state Rac activity; bottom panels: steady-state Rho activity. (a) Rac-dominated polarity is shown. (b) Balanced polarity is shown. (c) Rho-dominated polarity is shown. (d) Quantification of GTPase spatial gradient strength for each regulatory phenotype is shown (the difference between maximal GTPase activity and minimal GTPase activity from each panel). Parameters are the same as in Fig. 4. See Videos S1, S2, and S3 for animations. For details on numerical methods and initial conditions, see Numerical Methods for PDE Simulations. To see this figure in color, go online.