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. 2020 Feb 4;118(6):1438–1454. doi: 10.1016/j.bpj.2020.01.035

Table 1.

Well-Mixed, LPA, and PDE Parameter Screen Results

Parameter Sets Polarizable (Stimulus Required) Polarizable (Linearly Unstable) Not Polarizable
LPA Screen Monostable 890,309 66.3% 10.4% 23.3%
Bistable 90,305 55.7% 44.3% 0%
Tristable 19,101 84.3% 15.7% 0%
PDE Screen Monostable 890,309 18.8% 8.0% 73.2%
Bistable 90,305 30.6% 36.6% 32.8%
Tristable 19,101 22.7% 11.3% 66%

From an initial 106 parameter sets, the number of mono-, bi-, and tristable sets was determined (285 parameter sets were omitted; see Computational Approach Details for details). “Polarizable (stimulus required)” refers to parameter sets that require a sufficiently large perturbation from an HSS to polarize. “Polarizable (linearly unstable)” refers to those parameter sets that are LPA unstable (LPA Screen) or those parameter sets that are unstable with respect to noise around one or more HSSs in the PDE Screen. “Not Polarizable” refers to parameter sets that did not polarize using our numerical parameters and initial conditions.