Table 4.
Descriptive statistics of cytokine, mRNA, and caspase-1 data.
| Sampling | n | Mean | Median | Min | Max |
|---|---|---|---|---|---|
| Cytokines | Plasma concentration (pg/ml) | ||||
| IL-1β | 85 | 0.032 | 0.027 | 0.001 | 0.107 |
| IL-18 | 85 | 482 | 439 | 219 | 1328 |
| IL-1Ra | 85 | 271 | 193 | 82 | 1490 |
| IL-18BP | 85 | 2348 | 2162 | 932 | 5954 |
| mRNA expression | Normalized expression, arbitrary unit | ||||
| IL1Β | 84 | 0.07 | 0.06 | 0.02 | 0.15 |
| IL18 | 84 | 1.40 | 1.29 | 0.77 | 2.74 |
| IL1RN | 84 | 0.74 | 0.64 | 0.15 | 2.52 |
| IL18BP | 84 | 0.96 | 0.93 | 0.19 | 1.88 |
| NLRP3 | 84 | 0.56 | 0.53 | 0.15 | 1.42 |
| PYCARD | 84 | 8.38 | 8.26 | 2.74 | 18.31 |
| CASP1 | 84 | 0.94 | 0.89 | 0.52 | 1.71 |
| IL6 | 84 | 0.004 | 0.004 | 0.001 | 0.010 |
| Caspase-1 enzymatic activity in monocytes | % of unstimulated control | ||||
| Unstimulated | 100 | 100 | 100 | 100 | |
| LPS | 75 | 147 | 149 | 109 | 191 |
| Pam3CSK4 | 75 | 151 | 153 | 115 | 184 |
| ATP | 35 | 120 | 119 | 61 | 241 |
| LPS+ATP | 35 | 159 | 157 | 89 | 250 |