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p53 responded to ROS production induced by DpdtC. (a) The upregulation of p53 could be attenuated by the addition of autophagy inhibitor, ROS scavenger, and the downregulation of NCOA4; (b) quantification of the changes of p53 and MDM2 from (a). The experiments were performed twice. ∗∗∗,&&&p < 0.01.
