Table 1.
Clinical, epidemiological and microbiological characteristics of 6 patients with CMV pneumonia
| Pt | Age/sex | Underlying disease | Plasma reactivation (days from allo-TPH) | Clinical manifestations (days from allo-TPH) | Radiological manifestations | Plasma VL (cop/mL) | BAL VL (cop/mL) | Antiviral treatment (days from allo-TPH) | Plasma VL-neg (days of treatment) | Development |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 59/F | CLL-B | (+21) |
Fe+SRI+cough (+22) |
Bilateral interstitial infiltrates, ground glass opacities, bilateral pleural effusion | <150 (<2.2 log) (+26) |
670 (2.8 log) (+26) |
GCV (+26) – foscarnet (+31) |
Yes (9) | Alive |
| 2 | 18/F | AML-M2 | NP |
Cough+crackles (+233) |
Bilateral interstitial infiltrates, ground glass opacities |
61 800 (4.8 log) (+247) |
>10 000 000 (>7.0 log) (+247) |
VGV (+247) | Yes (14) | Alive |
| 3 | 53/F | CLL | (+19) |
Fe+dyspnea+cough+roncus +wheezing (+263) |
Peribronchial thickening and pulmonary nodule | ND |
956 (3.0 log) (+271) |
VGV (+275) | - | Alive |
| 4 | 62/F | ALL-B | (+75) |
Cough+wheezing+secretions (+113) |
Lobar condensation, ground glass opacities |
2 230 (3.3 log) (+122) |
64 300 (4.8 log) (+122) |
VGC (+110) GCV (+120) |
No | Died (+127) |
| 5 | 21/F | AML | (+13) |
Fe+dyspnea+hypoxemia+hemoptisis (+20) |
Bilateral interstitial infiltrates, ground glass opacities, pericardial and pleural effusion |
538 (2.7 log) (+27) |
42 200 (4.6 log) (+27) |
GCV (+25) + foscarnet (+47) |
No | Died (+53) |
| 6 | 56/F | ALL-B | (+7) |
Fe+dyspnea (+12) |
Bilateral interstitial infiltrates, ground glass opacities, pericardial and pleural effusion |
265 (2.4 log) (+49) |
238 000 (5.4 log) (+49) |
GCV (+14) +foscarnet (+46) |
No | Died (+59) |
Abbreviations: AHSCT=allogeneic hematopoietic stem cell transplantation; BAL=bronchoalveolar lavage; F=female; Fe=fever; GCV=ganciclovir; Pt=patient; ND=not detected; NP=not performed; SRI=severe respiratory insufficiency; VGC=valganciclovir; VL=viral load.