Table 2.
Results by period (Before and after 2005): this before–after study compared medical intervention (HSCT) and medical complication (MDS–AL) frequencies i.e., the number of events per person-years observed, between before- and after-2005 groups, using the Mantel–Haensel test.
| Parameter | Before 2005 | After 2005 to 2019 | P |
|---|---|---|---|
| Patients at risk, n | 89 | 139a | |
| Cumulative follow-up, person-years | 1588 | 1327 | |
| HSCT | |||
| n | 4 | 12 | <0.01 |
| Ratio, person-years | 2.5 × 10–3 | 9 × 10–3 | |
| MDS–AL | |||
| n | 6 | 0 | <0.01 |
| Incidence ratio, person-years | 3.8 × 10–3 | 0 | |
| Deaths [cause], n | 4 [2 AML, 1 sepsis, 1 HSCT-related] | 3 [1 colon cancer, 1 sepsis, 1 HSCT-related] | |
| Median age at death, year | 6.8 | 36 | |
HSCT hematopoietic stem-cell transplantation, MDS–AL myelodysplasia–acute leukemia, AML acute myeloblastic leukemia.
a55 patients born after 2005; 84 patients born before 2005 and followed until 2019.