Figure 11.

Design of protein nanocage-polymer hybrids. (a) Representation of protein cage with polymer branches in the interior cavity with attachment sites for drugs or imaging agents. (b) A cross-sectional view of HSPG41C nanocage showing cysteine residues (red) in the interior cavity. (c) Scheme for the production of dendritic structure with the generation units indicated at the bottom⁷¹ (reprinted (adapted) from Abedin, M.J. et al. Synthesis of a cross-linked branched polymer network in the interior of a protein cage. J. Am. Chem. Soc. 131, 4346–4354. Copyright (2009), with permission from American Chemical Society).