Table 3.
Genetic effects on T cell subset proportions in virgin male and female mice
| Effect size | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Trait | Age a | Marker b | IM position c | IM sigd (%) | P(F)<e | P(e)<f | Allele effect | % Pointsg | S.E. h |
| CD4 | 8 | D3Mit25 | +0 | 10 | 0.0002 | 0.02 | C>B6 | 3.6 | 0.9 |
| CD4 | 8 | D3Mit73 | +9 | 5 | C>B6 | ||||
| CD4 | 8 | D8Mit51 | +1 | 5 | 0.0001 | 0.01 | C>B6 | 3.7 | 0.9 |
| CD4 | 8 | D9Mit104 | −3 | 5 | 0.0003 | 0.02 | C3>D2 | 3.4 | 0.9 |
| CD4 | 8 | D15Mit100 | ND | 0.0014 | 0.09 | D2>C3 | 2.8 | 0.9 | |
| CD4 | 18 | D12Mit105 | ND | 0.0011 | 0.09 | C>B6 | 4.3 | 1.3 | |
| CD4 | 18 | D13Mit57 | ND | 0.0009 | 0.07 | D2>C3 | 4.4 | 1.3 | |
| CD4P | 8 | D16Mit5 | ND | 0.0011 | 0.08 | C>B6 | 5.0 | 1.5 | |
| CD4V | 8 | D4Mit155 | ND | 0.0009 | 0.07 | D2>C3 | 5.0 | 1.5 | |
| CD4V | 8 | D9Mit12 | −4 | 5 | C>B6 | ||||
| CD8 | 8 | D8Mit190 | ND | 0.0006 | 0.04 | B6>C | 3.3 | 1.0 | |
| CD8 | 8 | D15Mit100 | ND | 0.0003 | 0.02 | C3>D2 | 3.5 | 1.0 | |
| CD8 | 8 | D19Mit10 | ND | 0.0004 | 0.03 | C3>D2 | 3.5 | 1.0 | |
| CD8M | 8 | D1Mit206 | +7 | 5 | 0.0005 | 0.05 | D2>C3 | 5.4 | 1.5 |
| CD8M | 8 | D11Mit168 | −1 | 10 | 0.0005 | 0.05 | D2>C3 | 5.3 | 1.5 |
| CD8M | 8 | D12Mit105 | +0 | 5 | 0.0004 | 0.04 | B6>C | 5.7 | 1.6 |
| CD8M | 18 | D1Mit221 | −8 | 5 | D2>C3 | ||||
| CD8M | 18 | D2Mit58 | ND | 0.0007 | 0.06 | B6>C | 7.9 | 2.3 | |
| CD8M | 18 | D12Mit105 | +0 | 5 | 0.0001 | 0.02 | B6>C | 8.5 | 2.2 |
aAge (8 or 18 months) at which association was noted.
bGenotypic markers with strongest association. Markers where P(e)<0.10 in the ANOVA calculations are shown in this table, supplemented by three QTL that were detected as significant only by using the interval mapping approach. Number of mice used for each calculation varied between 143 and 242.
cPosition of QTL estimated by interval mapping, stated in cM with respect to the indicated marker; a negative sign indicates an estimate closer to the centromere and a positive sign indicates a location further from the centromere. ND = not detected by the interval method.
d-hAs in Table 2.