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. 2011 May 13;18(7):489–499. doi: 10.1038/cgt.2011.18

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© Nature America, Inc. 2011

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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AdVova stimulates preventive ovalbumin (OVA)-specific antitumor immunity in wild-type C57BL/6 mice. (a) AdVova-immunized C57BL/6 mice were s.c. challenged with BL6-10ova tumor cells on day 11 after the immunization. One day before tumor challenge, mice were i.p. injected with anti-CD8 or anti-NK1.1 antibody (0.3 mg per mouse). The antibody treatment was repeated once every 3 days for a total of five times. (b) AdVova-immunized C57BL/6 mice were s.c. challenged with BL6-10ova tumor cells on day 60 after the immunization. Tumor growth was monitored. One representative experiment of two is shown. AdV, adenovirus; NK, natural killer.