Fig. 7.

Muscle transduction by bat AAV 10HB mutants at the selected sites 259 and 691. A total of 10¹⁰ vector genomes of AAV2, wild-type or mutated bat AAV 10HB vectors as indicated were intramuscularly injected into the gastrocnemius muscle of adult C57B/6 mice, and luciferase activity (a) and rAAV vector genome copies (b) were detected 14 days after treatment. The data are mean values ± s.e.P-values from the unpaired two-tailed t-test are shown above the bars