Table 3.
Detection of positive selection during evolution of bat AAV capsid genes
| Bat AAV lineages | Positively selected sites in bat AAV capsids | Correspondent residues in AAV2 capsid |
|---|---|---|
| Branch-site test | ||
| The whole bat AAV lineage | S238 and M420 in 09YN capsid; or S238 and M418 in 10HB capsid | A248 and A425 |
| 07YN/09YN/1285 lineage | N344 in 09YN capsid | S356 |
| 10HB branch | Q213, R297, A422 and M664 in 10HB capsid | N223, K309, S429 and V678 |
| MEME | ||
| The whole bat AAV lineage | S238 in 09YN capsid; or S238 in 10HB capsid | A248 |
| 07YN/09YN/1285 lineage | T259, N344 and E694 in 09YN capsid | H271, S356 and N705 |
| 10HB branch | S214 in 10HB capsid | S224 |
Note: The correspondent sites in AAV2 capsid were determined by checking the related sequence alignment of dependovirus capsid genes generated by PRANKSTER