Table 2.
Body weight, adiposity, and plasma measurements in rats fed with standard chow diet (SD) or high-fat diet (HFD) for 6 weeks along with transduction in the nucleus of the solitary tract of GFP (SD-eGFP and HFD-eGFP) or AT2R (SD-AT2R and HFD-AT2R)
| SD-eGFP | HFD-eGFP | SD-AT2R | HFD-AT2R | |
|---|---|---|---|---|
| Initial body mass (g) | 309 ± 1 (n = 6) | 307 ± 1 (n = 7) | 309 ± 1 (n = 5) | 306 ± 1 (n = 7) |
| Final body mass (g) | 387 ± 13 (n = 6) | 471 ± 9* (n = 7) | 393 ± 12 (n = 5) | 440 ± 13a (n = 7) |
| Epididymal adipose tissue (g/100 g body mass) | 0.35 ± 0.03 (n = 6) | 0.91 ± 0.07* (n = 7) | 0.45 ± 0.06 (n = 5) | 0.80 ± 0.06* (n = 7) |
| Retroperitoneal adipose tissue (g/100 g body mass) | 0.43 ± 0.03 (n = 6) | 1.18 ± 0.08* (n = 7) | 0.47 ± 0.05 (n = 5) | 1.16 ± 0.08* (n = 7) |
| Mesenteric adipose tissue (g/100 g body mass) | 0.44 ± 0.05 (n = 6) | 0.83 ± 0.06* (n = 7) | 0.39 ± 0.03 (n = 5) | 0.70 ± 0.03* (n = 7) |
| Total cholesterol (mg/dl) | 64 ± 5.7 (n = 6) | 93 ± 2.5* (n = 7) | 60 ± 2.4 (n = 5) | 86 ± 3.23* (n = 7) |
| HDL (mg/dl) | 38 ± 2.3 (n = 6) | 38 ± 3.3 (n = 7) | 34 ± 2.2 (n = 5) | 40 ± 1.5 (n = 7) |
| TGL (mg/dl) | 54 ± 4.4 (n = 6) | 79 ± 2.9* (n = 7) | 51 ± 3.9 (n = 5) | 84 ± 6.1* (n = 7) |
| Leptin (ng/ml) | 0.48 ± 0.12 (n = 4) | 1.89 ± 0.20* (n = 6) | 0.39 ± 0.05 (n = 4) | 2.55 ± 0.28* (n = 5) |
All values are presented as means±SEM. One-way ANOVA followed by the Student–Newman–Keuls test. Total cholesterol, HDL, TGL, and leptin levels were measured after 12 h fasting
HDL high-density lipoprotein, TGL triacylglycerol
*Different from SD; P < 0.05