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. 2018 Sep 24;53(Suppl 1):19–144. doi: 10.1038/s41409-018-0318-y

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© Springer Nature Limited 2018

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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[[O089 Figure] — Reductions in oral intake increase intestinal bacterial mucolytic activity.]

(A) Effects of ROI on intestinal bacterial composition. NOI indicates normal oral intake. (B) Functional mucolytic assay; remaining mucin levels after 48-hour culture with indicated bacterial sources. (C) Histological thickness of the inner mucus layer in mice. (D) Functional mucolytic assay using patient fecal specimens. Above: 4 patients without increases in mucolytic function. Below: 4 patients with increases in mucolytic function. (E) Effects of ROI on colonic luminal pH. (F) Effects of pH on Akkermansia mucolytic function in vitro. (G) Effects of supplemental sugars on colonic mucus thickness.