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. Author manuscript; available in PMC: 2020 Mar 24.
Published in final edited form as: Curr Alzheimer Res. 2018;15(7):655–663. doi: 10.2174/1567205015666180119104036

Fig. (3). Impact of TA on acquisition and memory retention in 16–18-month old hTau knock-in mice.

Fig. (3).

Training in the Morris water maze consisted of three trials per day for 8 days to locate a hidden platform. (A) Mean escape latencies for finding the platform during daily training sessions. (B) Average swimming speed of Control carrier (C, Tau+/+) and carrier mice administered with TA (TA 5mg, Tau+/+) along the 8-day session. (C) Memory retention was assessed by a 60-second probe trial 24 hours (Probe trial 1) after the last day of acquisition testing and again repeated for memory retention after 10 days (Probe trial 2). The trials measure the time spent in the platform zone of the correct quadrant. Values are expressed as mean ± standard error of the mean**.