Table 3.

Subphenotype-specific treatment response in the reanalyses of outcomes in four different clinical ARDS trials

Intervention/trial cohort analyzed		Hypoinflammatory subphenotype response		Hyperinflammatory subphenotype response
	Outcome	Intervention	Control	Intervention	Control
High vs. low PEEP/ ALVEOLI* [27]	90-day mortality	24% high PEEP	16% low PEEP	42% high PEEP	51% low PEEP
Conservative vs. liberal fluid strategy/ FACCT* [29]	90-day mortality	18% conservative fluid strategy	26% liberal fluid strategy	50% conservative fluid strategy	40% liberal fluid strategy
Simvastatin/ HARP-2 [40]	28-day survival	No difference		Improved survival with simvastatin (p = 0.008)
Rosuvastatin/SAILS [41]	90-day mortality	No difference		No difference

PEEP positive end-expiratory pressure; ^∗p value <0.05 for interaction between treatment and subphenotype