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. 2020 Mar 23;19:38. doi: 10.1186/s12933-020-01011-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Loess spline curves of long-term LVEF trajectories in diabetic patients based on clinical modifiers. a Aetiology: ischemic (blue) vs. non-ischemic (yellow) aetiology. P for trajectory changes on LVEF < 0.001 for both groups. P for comparison between groups < 0.001. Shaded regions displayed around curves represent the confidence interval at level = 0.95. b HF Duration: ≤ 12 months (blue) vs. > 12 months (yellow). P value for trajectory changes on LVEF < 0.001 for both groups. P for comparison between groups < 0.001. Shaded regions displayed around curves represent the confidence interval at level = 0.95. c Sex: women (blue) vs. men (yellow). P for trajectory changes on LVEF < 0.001 for both sexes. P for comparison between sexes < 0.001. Shaded regions displayed around curves represent the confidence interval at level = 0.95. d Optimal (blue) vs. non-optimal glycemic (yellow) control. P for trajectory changes on LVEF < 0.001. P for comparison between glycemic control groups 0.35. Shaded regions displayed around curves represent the confidence interval at level = 0.95