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. 2020 Mar 23;20:97. doi: 10.1186/s12906-020-2880-2

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Effects of 100 μg/mL silymarin on the attachment and entry of EV-A71 to Vero cells. a The viral attachment inhibition was calculated as the number of plaques formed by the silymarin-treated virus over the number of plaques formed by the untreated virus. b Viral entry inhibition was calculated as the number of plaques formed by the virus treated with silymarin after attachment to the cells over the number of plaques formed by the untreated virus. Data presented as mean ± S.E.M. Error bars indicate the range of values obtained from three independent experiments. *** p < 0.001 indicates a significant difference in between groups compared by t-test