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Flow chart of patients’ cohort definition. Data from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute in the United States, covering approximately 28% of cancer cases in the United States were used for the present population-based analysis. Of 217,068 patients diagnosed with colorectal cancer between 2010 and 2015, 10,325 were eligible for analysis at the end of the selection process
