Table 1.
Descriptive data of subjects with AST/ALT ratio < 1 and ≥ 1
| Parameter | Group-1 (58 patients) [AST/ALT ratio < 1] | Group-2 (47 patients) [AST/ALT ratio ≥ 1] | P-value |
|---|---|---|---|
| Age (year) | 50.03 ± 15.25 (16–82) | 50.17 ± 14.18 (21–88) | 0.915 |
| Gender (n, %) | 44 males (75%) | 24 males (51%) | 0.009 |
| Heart failure Duration (year) | 5.43 ± 2.46 (2–12) | 4.55 ± 3.09 (1–13) | 0.021 |
| NYHA–class | 2.12 ± 1.04 (1–4) | 2.49 ± 0.86 (1–4) | 0.042 |
| Diabetes mellitus (n, %) | 37 (63.8%) | 26 (55.32%) | 0.052 |
| Hypertension (n, %) | 33 (56.9%) | 25 (53.2%) | 0.632 |
| Smoking (n, %) | 10 (17.24%) | 11(23.4%) | 0.493 |
| BMI (kg/m2) | 28.72 ± 5.8 (16–40) | 30.33 ± 9.42 (17.6–70) | 0.609 |
| Systolic BP (mmHg) | 123.19 ± 20.19 (90–185) | 127.02 ± 17.5 (100–171) | 0.248 |
| Diastolic BP (mmHg) | 73 ± 11.57 (52–99) | 73.68 ± 10.63 (50–111) | 0.701 |
| Hemoglobin (g/dL) | 13.65 ± 1.76 (9.2–17.7) | 12.86 ± 2.18 (7.5–16.3) | 0.086 |
| Platelets (× 109/L) | 267.68 ± 72.25 (137–422) | 299.71 ± 94.94 (149–588) | 0.180 |
| Fasting blood sugar (mmol/L) | 15.62 ± 27.62 (4.38–140) | 10.24 ± 6.44 (4.82–24.8) | 0.874 |
| Potassium+ (mEq/L) | 4.2 ± 0.52 (3.1–5.8) | 4.1 ± 0.58 (2.8–5.7) | 0.415 |
| Sodium+ (mEq/L) | 136.96 ± 4.43 (127–146) | 135.98 ± 3.83 (127–143) | 0.261 |
| Serum creatinine (mmol/L) | 109.57 ± 80.95 (50–581) | 114.86 ± 97.72 (57–538) | 0.741 |
| Blood urea (mmol/L) | 7 ± 3.36 (2.7–19) | 7.34 ± 5.27 (2.8–30.6) | 0.588 |
| Total cholesterol (mmol/L) | 3.99 ± 1.13 (1.06–5.86) | 4.35 ± 1.64 (1.2–7.8) | 0.373 |
| HDL cholesterol (mmol/L) | 0.93 ± 0.25 (0.53–1.39) | 0.99 ± 0.35 (0.25–1.68) | 0.459 |
| Triglycerides (mmol/L) | 2.08 ± 1.36 (0.51–6.36) | 1.57 ± 0.99 (0.64–4.94) | 0.068 |
| T3 (nmol/L) | 5.25 ± 2.75 (1.11–16.95) | 6.87 ± 4.78 (4.07–17.67) | 0.655 |
| T4 (nmol/L) | 13.64 ± 5.15 (1.62–20.7) | 13.75 ± 4.46 (3.71–19.99) | 0.981 |
| TSH (mIU/L) | 9.15 ± 32.54 (1–193) | 6.6 ± 10.05 (0.19–48) | 0.899 |
| Bilirubin (mg/dL) | 11.88 ± 11.63 (3–67.9) | 12.75 ± 12.2 (0.7–64) | 0.722 |
| Albumin (g/dL) | 36.02 ± 4.51 (24.2–45.4) | 33.68 ± 8.61 (38–44.2) | 0.492 |
| aPTT (s) | 38.08 ± 20.72 (16–126) | 35.38 ± 13.57 (18–84.3) | 0.549 |
| INR | 1.15 ± 0.15 (1–1.6) | 1.22 ± 47 (0.94–3.7) | 0.737 |
| AST (IU/L) | 32.03 ± 50.31 (10–351) | 75.17 ± 163.59 (7–763) | 0.195 |
| ALT (IU/L) | 52.05 ± 71.05 (15–520) | 25.57 ± 24.37 (4–121) | 0.001 |
| GGT (U/L) | 89.67 ± 101.8 (6–203) | 25.48 ± 19.33 (6–52) | 0.479 |
| ALP (U/L) | 102.38 ± 57.81 (48–385) | 98.89 ± 53.14 (34–276) | 0.449 |
| AST/ALT ratio | 0.63 ± 0.19 (0.16–0.94) | 1.3 ± 0.25 (0.95–1.85) | 0.001 |
| APRI index | 0.31 ± 0.41 (0.09–2.8) | 0.74 ± 1.76 (0.07–8.03) | 0.877 |
| FIB-4 score | 0.8 ± 0.43 (0.17–1.96) | 1.1 ± 0.81 (0.3–3.6) | 0.002 |
| NT-proBNP (pg/mL) | 1212.9 ± 1869.2 (8.4–8455) | 1845.6 ± 2271.8 (4.1–9595) | 0.089 |
| LVEF (%) | 28.93 ± 10.26 (16–43) | 23.83 ± 7.04 (14–36) | 0.012 |
| SPAP (mmHg) | 42.33 ± 19.03 (15–63) | 45.25 ± 13.34 (22–70) | 0.344 |