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. 2020 Mar 23;12:29. doi: 10.1186/s13195-020-00598-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The association between the AD-specific chromatin-accessible regions and gene expression in AD mice. a ATAC-seq signal at TSSs correlates quantitatively with gene expression, the left figures (in blue) show the correlation between ATAC-seq signal at TSS and gene expression in AD mice, and the right figures (in pink) show the correlation between ATAC-seq signal at TSS and gene expression in WT mice. b Volcano plot of differentially expressed genes in AD, upregulated genes are shown by red dots and downregulated genes are shown by blue dots. c Venn diagram showing genes associated with the chromatin-accessible regions in AD and differentially expressed genes. d Upregulated genes in AD that are associated with AD-specific open chromatin regions. e Downregulated genes in AD that are associated with AD-specific closed chromatin regions