Fig. 4.

RNA-seq gene expression analysis in the hippocampus of AD and WT mice. a Heatmap of 50 most variable genes are listed based on RNA-seq. b Changes in chromatin accessibility downstream of the APP gene. Track in blue shows normalized and input-corrected ATAC-seq signal in WT mice and track in red shows normalized and input-corrected ATAC-seq signal in APP/PS1 mice. The chromatin-accessible regions are indicated with blue bars (WT mice) or red bars (AD mice) on the middle area of the graph and the TSS is shown by blue arrow