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. 2020 Mar 24;17:13. doi: 10.1186/s12950-020-00242-8

Fig. 7.

Fig. 7

A schematic of the proposed mechanism. During degeneration, MAPK and NF-κB signaling are activated by IL-1β stimulation. UA treatment can decrease iNOS, COX2, and MMPs expression and increase matrix gene expression through inhibiting activation of the MAPK and NF-κB pathways