Sherbaf 2012.

Trial name or title	Comparison the effect of daily versus twice weekly usage of iron supplementation on pregnancy outcomes in nonanaemic pregnant women.
Methods	Randomised controlled trial with 2 arms.
Participants	508 singleton non‐iron deficient non‐anaemic pregnant women (Hb 110‐138 g/L and ferritin 10‐300 ng/mL) with less than 18 weeks of gestation, no history of smoking or use of glucocorticoid and sympathomimetic drugs, and no history of asthma or chronic hypertension, gestational diabetes, pre‐eclampsia or overt diabetes in previous pregnancies attending The Great Women Hospital in Tehran, Islamic Republic of Iran. Women with Hb concentrations less than 105 g/L in second trimester or less than 110 g/L in third trimester will be excluded from the study.
Interventions	Participants will be randomly assigned to 1 of 2 groups: group 1 (n = 254) will receive 50 mg elemental iron (as ferrous sulphate) daily from 20 weeks of gestation until delivery; group 2 (n = 254) will receive 50 mg elemental iron (as ferrous sulphate) twice a week from 20th week of gestation until delivery.
Outcomes	Primary: gestational diabetes at gestational age of 24‐28 weeks and at 32‐36 weeks of gestation, pre‐eclampsia, birthweight of neonate, low birthweight. Secondary: any adverse effects, nausea,vomiting, constipation, metallic oral taste, Hb concentrations, ferritin concentrations at 24‐28 weeks and at 32‐36 weeks of gestation.
Starting date	10 February 2012.
Contact information	Dr Fateme Rahimi Sherbaf Mirza Kuchack Khan Hospital (Women Hospital), North Nejatolahi Street, Tehran 15978, Islamic Republic of Iran Tel: +98 21 88900002 Email: rahimish@tums.ac.ir
Notes	Sponsor: Tehran University of Medical Sciences.

Hb: haemoglobin
 IUGR: intrauterine growth restriction