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. 2015 Dec 10;2015(12):CD011134. doi: 10.1002/14651858.CD011134.pub2

Summary of findings 3. Outcome of follow‐up testing using a CEA threshold of 5 µg/L.

Month when CEA measured per 1000 patients tested at a threshold of 5 µg/L False alarm rate
Estimated recurrences¹ Referrals for raised CEA Cases of recurrence detected Cases of recurrence missed False alarms (cases investigated when cancer not present)
Follow‐up years 1 and 2: 3‐monthly CEA testing
3 19 131 13 6 118 90%
6 19 131 13 6 118 90%
9 39 143 28 11 115 80%
12 39 143 28 11 115 80%
15 37 142 26 11 116 82%
18 37 142 26 11 116 82%
21 31 138 22 9 116 84%
24 31 138 22 9 116 84%
Follow‐up years 3, 4 and 5: 6‐ monthly CEA testing
30 46 147 33 13 114 78%
36 36 142 26 10 116 82%
42 27 136 19 8 117 86%
48 25 135 18 7 117 87%
54 17 130 12 5 118 91%
60 14 128 10 4 118 92%

1Estimates are based on data reported by Sargent 2007. Three‐monthly data were unavailable, and so constant rates were assumed during each six‐month period for the first two years. Estimates are rounded.