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. 2020 Mar 17;8:170. doi: 10.3389/fbioe.2020.00170

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Copyright © 2020 Zhang, Zhang, Wang, Wang, Bai, Zhang, Zhao, Yu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSNs@PCM@TP downregulated the activation of the immune system in the RA rat model. (A) The maximum absorption peak of TP in PBS (pH 7.4) was found by full wavelength scanning. (B) The temperature changing of MSNs@PCM under 808 nm laser. (C) Encapsulation efficiency profiles of the MSNs@PCM@TP for TP were determined by use of semipermeable dialysis bags in PBS (pH 7.4) at 37°C. (D,E) mRNA and protein expression of PTPN22 in the thymus and spleen of RA rat treated with 100 μg/ml MSNs@PCM@TP under 808 nm laser irradiation for 1 week as detected by qPCR and Western blot assay, respectively. (F–H) Serum levels of IL-2, IL-6, and TNF-α in rats treated with 100 μg/ml MSNs@PCM@TP under 808 nm laser irradiation for 1 week, as determined by ELISA. Experiments were repeated three independent times (^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001).