TABLE 1.

The appropriate dose and method of administration in rats.

Group	Administration method	Drugs	Dose
Control group	I.P.	PBS (pH 7.5)	2 ml/time
RA model group	I.P.	PBS (pH 7.5)	2 ml/time
Methotrexate (MTX) group	I.P.	MTX	2.5 mg/kg
TP group	I.P.	TP	50 μg/kg
MSNs@PCM@TP group + 808 nm laser	I.P.	MSNs@PCM@TP	100 μg/ml
MSNs@PCM@TP group	I.P.	MSNs@PCM@TP	100 μg/ml
MSNs@CADY@miR-30-5p inhibitor group	I.C.	MSNs@CADY@miR-30-5p inhibitor	100 μg/ml
MSNs@CADY@miR-30-5p inhibitor + I.P. MSNs@PCM@TP + 808 nm laser group	I.C. (MSNs@CADY@miR-30-5p inhibitor), I.P. MSNs@PCM@TP + 808 nm laser	MSNs@CADY@miR-30-5p inhibitor + I.P. MSNs@PCM@TP + 808 nm laser	100 μg/ml MSNs@CADY@miR-30-5p inhibitor + 100 μg/ml I.P. MSNs@PCM@TP + 808 nm laser