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. 2020 Mar 17;11:111. doi: 10.3389/fendo.2020.00111

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Copyright © 2020 Lv, Le, Xiang, Jiang, Chen and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MET and EMP alter liver transcription. Rat livers were collected and then subjected to RNA-seq gene expression analysis. (A) The number of upregulated (blue) and downregulated (red) genes from the MOD/control, MET/MOD, and EMP/MOD categories in the rat liver genome. (B) 3D view of PLS-DA analysis of the control, MOD, MET, and EMP groups. (C) The Venn diagram shows an overlap among the MOD/control, MET/MOD, and EMP/MOD genes. (D) Heat maps of the most differentially expressed genes from control, MOD, MET, and EMP comparisons. Each column represents an individual animal.