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. 2020 Mar 17;11:111. doi: 10.3389/fendo.2020.00111

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Copyright © 2020 Lv, Le, Xiang, Jiang, Chen and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MET and EMP downregulate genes. (A) Functional enrichment of MET/MOD-specific DEGs with the highest FDR values. (B) Functional enrichment of EMP/MOD-specific DEGs with the highest FDR values. (C) Heat maps of most DEGs involved in metal ion binding. (D) Protein processing in the endoplasmic reticulum common gene network indicates DEGs downregulated by MET and EMP (green) and DEGs downregulated by MET but not by EMP (red). (E) The PI3K-Akt signaling pathway. Each column represents one individual animal.