Table 1.
Genes Analyzed in Experimental Myopia Studies
| Authors | Year | Chromosome Location | Candidate Genes | Methodology | Study Ethnicity |
|---|---|---|---|---|---|
| Young et al160 | 1998 | 12q 21-23 | TNL | Linkage Study | E |
| Young et al161 Scavello et al162 |
2001 | 18p 11.31 | TGIF | Linkage Study | A & E |
| Paluru et al163 | 2003 | 17q 21-22 | Unidentified | Linkage Study | En & Cn |
| Hammond et al164 | 2004 |
11p 13 3q 26 8p 23 4q 12 |
PAX6 | GWLS | E |
| Stambolian et al165 | 2004 | 22q 12.3 | Unidentified | GWLS | AJ |
| Zhang et al166 | 2005 | 4q 22-27 | RRH | Linkage Study | A |
| Paluru et al167 | 2005 | 2q 37.1 | SAG DGKD |
GWLS | E |
| Wojciechowski et al168 | 2006 | 1p 36 | ~189 genes | GWLS | AJ |
| Zhang et al169 | 2006 | Xq 23-25 | Unidentified | Linkage Study | A |
| Nallasamy et al170 | 2007 | 10q 21.1 | Unidentified | Linkage Study | E |
| Ciner et al171 Paget et al172 |
2008 | 7p 15 | ~170 genes | GWLS | AA E & Af |
| Lam et al173 | 2008 | 5p 15.33–15.2 | IRX2 | GWLS | A |
| IRX1 | |||||
| POLS | |||||
| CCT5 | |||||
| CTNND2 | |||||
| LOC442129 | |||||
| Ciner et al174 | 2009 | 20, 11 | Unidentified | Linkage Study | AA & W |
| Yang et al175 | 2009 | 14q 22.1–24.2 | Unidentified | GWLS | A |
| Hysi et al176 | 2010 | 15q 25 | TNL | GWAS | E |
| Solouki et al177 | 2010 | 15q 14 | GJD2 ACTC1 |
GWAS | D |
| Ma et al178 | 2010 | 5p 13.3–15.1 | CDH6 | GWLS | A |
| CDH10 | |||||
| CDH12 | |||||
| PDZD2 | |||||
| GOLPH3 | |||||
| ZFR | |||||
| Guo et al179 | 2010 | Xq 28 | Unidentified | Linkage Study | A |
| Rydanicz et al180 | 2011 |
7p 22.1–21.1 7p 12.3–11.2 12p 12.3–12.1 |
TNL | Linkage Study | P |
| Han et al181 | 2011 |
1P 36.6 4q 12 |
FRAP1 PDGFRA |
GWAS | A |
| Yu et al182 | 2012 |
11q 24.1 5p 15.2 |
TNL CTNND2 |
Association Analysis | C |
| Abbott et al183 | 2012 |
6q 13–16.1 5q 35.1–35.2 |
TNL | QTL Linkage Study | W |
| Fan et al184 | 2012 | 1q 41 | ZC3H11A | GWAS-Meta | A |
| SLC30A10 | |||||
| LYPLAL1 | |||||
| Mishra et al185 | 2012 | 4q 12 | PDGFRA | Meta- Analysis | Au |
| Cheng et al186 | 2013 | 1p 34.3 | RSPO1 | GWAS-Meta | E & A |
| 3q 12.1 | C2orf26 | ||||
| 6q 22.33 | LAMA2 | ||||
| 15q 14 | GJD2 | ||||
| 22q 12.1 | ZNRF3 | ||||
| 1q 32.2 | CD55 | ||||
| 12q 13.3 | MIP | ||||
| 2q 37.1 | ALPPL2 | ||||
| 1q 41 | ZC3H11B | ||||
| Guggenheim et al187 | 2013 | 4q 12 | PDGFRA | GWAS | E |
| Wang et al188 | 2014 | 1p 22.2 | ZNF644 | Association Analysis | C |
| Chen et al189 | 2015 | 15q 25.1 | RASGRF1 | Meta-Analysis | C & J |
| Wang et al190 | 2016 | 5p 35.5 | GRM6 | CC Association Analysis | C |
| Liao et al191 | 2017 | 6q 13 | KCNQ5 | Case-control study | C |
| Musolf et al192 | 2017 | 11p | TNL | Linkage Study | W |
| Musolf et al193 | 2018 | 10q 26.13 | TNL | Linkage study | C |
| Wojciechowski et al194 | 2018 |
12q 24 4q 21 |
TNL | GWLS | Am, AA, AJ & W |
Notes: Characters in Bold denote Chromosome number
Abbreviations: TNL, Too Numerous to List; GWAS, Genome Wide Association Studies; GWLS, Genome Wide Linkage Scan; QTL, Quantitative Trait Locus; CC, Case–control Study; A, Asian; AA, African American; Af, African; AJ, Ashkenazi Jews; Am, Old Order Amish; Au, Australian; C, Chinese; Cn, Canadian; D, Dutch; E, European; En, English; J, Japanese; P, Polish; W, Caucasian.