Skip to main content
. Author manuscript; available in PMC: 2021 Apr 15.
Published in final edited form as: Arch Biochem Biophys. 2020 Feb 12;683:108299. doi: 10.1016/j.abb.2020.108299

Figure. 3:

Figure. 3:

ER stress led to decreased oxidative phosphorylation and increased cell death in H9c2 cells.

Panel A: THAP treatment led to decreased oxidative phosphorylation in H9c2 cells oxidizing complex I substrates. THAP did not markedly alter oxidative phosphorylation in H9c2 cells oxidizing complex II substrates.

Panel B: THAP-induced ER stress increased cell death in H9c2 cells. Prevention of calpain activation using MDL-28170 (10 uM) led to decreased cell death in H9c2 cells, indicating that ER stress-mediated calpain activation contributes to cell death. Mean ± SEM. *p<0.05 vs. vehicle. N=4 in each group.