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Functional characterization of ClC-Kb mutants expressed in HEK 293 cells. (A) Representative chloride current traces of ClC-Kb wild type, G167V, G289R, and A242E channels (5 µg) co-expressed with equal amount of barttin (1:1 ratio) in HEK 293 cells. (B) IV plot showing the mean current amplitude of the indicated channels as a function of membrane potential. Data are mean ± SE; n = 11–19 cells.
