TABLE 2.
Lipid and non-lipid targets of SREBF genes generated from the Chip-Atlas database (https://chip-atlas.org/).
| Biological Function | Target Genes |
| SREBF1 MUS MUSCULUS | |
| Lipid biosynthesis | Srebf1; Srebf2 |
| Non-lipid targets | |
| Antiport system | Clcn4 |
| Associated protein of endosomal sorting complex | Brox |
| Cytoskeleton and ECM | Sspn |
| RNA polymerase activity | Polr3g |
| Essential factor for protein synthesis | Eef2 |
| Cell matrix adhesion | Sorbs1; Cldn34d |
| Glycolytic enzyme | Pgk1 |
| Hydrolase activity | Mblac2 |
| Induction of apoptosis | Dapk3 |
| Interleukin-31 receptor signaling | Il31ra |
| Lipase activity | Abhd6 |
| Nuclear protein import | Kpna1 |
| Phosphatase activity | Pdp2 |
| Structural protein of centrosome | Sfi1 |
| Trace-amine receptor | Taar6; Taar7a |
| Transmembrane protein | Tmem125 |
| Ventralizing factor in embryogenesis | Aida |
| SREBF1 HOMO SAPIENS | |
| Lipid biosynthesis | ACACA, ACAT2, ACLY, ACSL3, ACSS2, CYP51A1, DHCR7, FADS2, FAS, FDFT1, FDPS, HMGCR, HMGCS1, HSD17B12, HSD17B7, IDI1, LSS, MSMO1, MVD, MVK, SC5D, SCD, SQLE, SREBF1, SREBF2, STARD4 |
| Non-lipid targets | |
| Adiponectin signaling | ADIPOR2 |
| Biosynthesis of coenzyme A | PANK3 |
| Cell matrix adhesion | SDCBP2 |
| Glutathione metabolism | SOD2 |
| Mitochondrial translation | MRPS15 |
| Peroxisome organization, mitochondrial fission | TMEM135 |
| Phospholipase activity | PLA2G6 |
| Transcriptional regulator | FOXK2 |
| Transmembrane transporter | SLCO4C1 |
| SREBF2 HOMO SAPIENS | |
| Lipid biosynthesis | SREBF2; HMGCS1 |
| Non-lipid targets | |
| Anti-apoptotic | MT-RNR2L |
| De novo synthesis of purines, thymidylic acid | DHFR |
| DNA mismatch repair | MSH3 |
| ECM constituent | EMILIN2 |
| Ribosome biogenesis | WDR74 |