Table 2. Serum Uric Acid Level, Serum Uric Acid/Creatinine Ratio and Serum Bilirubin Levels According to Clinical Characteristics of Parkinson’s Disease.
| Total cases (N) | SUA (µmol/L) | SUA/SCr ratio | Total bilirubin (µmol/L) | Indirect bilirubin (µmol/L) | |
|---|---|---|---|---|---|
| PD disease severity (based on H&Y stage) | |||||
| Mild (1 - 2) | 36 | 315.74 ± 81.76 | 4.20 ± 0.88 | 7.65 (6.71 - 8.72)a | 4.28 (3.68 - 4.97)c |
| Moderate (2.5 - 3) | 11 | 269.82 ± 65.06 | 3.71 ± 0.80 | 8.72 (6.89 - 11.04)b | 4.93 (3.79 - 6.42)d |
| Severe (4 - 5) | 14 | 301.65 ± 93.94 | 4.24 ± 0.99 | 5.56 (4.46 - 6.94) | 2.96 (2.20 - 4.00) |
| P value | 0.222 | 0.271 | 0.010 | 0.014 | |
| PD disease duration (years) | |||||
| < 2 years | 9 | 321.85 ± 56.54 | 4.10 ± 0.45 | 7.70 (6.04 - 9.80) | 4.08 (2.89 - 5.77) |
| ≥ 2 years | 52 | 301.17 ± 86.32 | 4.12 ± 0.96 | 7.21 (6.41 - 8.11) | 4.03 (3.51 - 4.62) |
| P value | 0.556 | 0.936 | 0.669 | 0.906 | |
| Motor symptom subtypes | |||||
| PIGD | 44 | 297.94 ± 89.27 | 3.99 ± 0.89 | 7.09 (6.33 - 7.93) | 3.94 (3.44 - 4.50) |
| Tremor | 10 | 321.19 ± 46.33 | 4.55 ± 0.82 | 8.96 (6.28 - 12.77) | 4.81 (3.09 - 7.50) |
| P value | 0.343 | 0.079 | 0.082 | 0.235 | |
Data are presented as mean ± SD and geometric mean (95% CI). The analysis was controlled by age and co-morbidities. PD: Parkinson’s disease; H&Y: Hoehn-Yahr; PIGD: postural instability/gait difficulty; SUA: serum uric acid; SUA/SCr: serum uric acid/serum creatinine. aP = 0.009 (total bilirubin; mild vs. severe disease); bP = 0.005 (total bilirubin, moderate vs. severe disease); cP = 0.012 (indirect bilirubin, mild vs. severe disease); dP = 0.008 (indirect bilirubin, moderate vs. severe disease). a-dAnalyzed by Fisher’s least significant difference (LSD) test.