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. 2018 Sep 6;188:213–224. doi: 10.1016/j.actatropica.2018.09.003

Fig. 2.

Fig. 2

Algorithm for arbovirus diagnosis in suspect cases of chikungunya, dengue and Zika diseases. (A) Samples should be tested by RT-PCR due to the cross-reaction observed in flavivirus samples. (B) Once the molecular test is negative, serological test must be performed. *perform serological tests for samples collected ≥ 4 days after the onset of clinical signs and symptoms; **PRNT is required due to the cross-reaction between DENV and ZIKV; ***Test also for other flavivirus (e.g. West Nile and Saint Louis encephalitis viruses). Reference: CDC (2016) and PAHO (2017).