Table 1.

Comparison of mRNA stabilities between intron-containing genes and intronless genes

Species, cell types/strains	mRNA stability indicator	Gene category	n	Mean ± SEM	Median	P valuea
Homo sapiens
HepG2	Decay rate (h−1)	Intronless	43	0.421 ± 0.068	0.25	9.8 × 10−7
		Intron-containing	3414	0.168 ± 0.003	0.113
Bud8	Decay rate (h−1)	Intronless	54	0.343 ± 0.053	0.2	1.6 × 10−4
		Intron-containing	3142	0.180 ± 0.003	0.15
T lymphocytes (with medium)	Half-life (min)	Intronless	78	1104 ± 157	377.5	9.4 × 10−4
		Intron-containing	3933	1591 ± 25	1045
T lymphocytes (with anti-CD3)	Half-life (min)	Intronless	78	987 ± 150	156.25	0.045
		Intron-containing	3933	986 ± 21	231
T lymphocytes (with anti-CD3 and anti-CD28)	Half-life (min)	Intronless	78	873 ± 139	134	5.4 × 10−4
		Intron-containing	3933	1216 ± 24	310
Saccharomyces cerevisiae
Strain Y262	Half-life (min)	Intronless	4016	25.3 ± 0.332	20	2.1 × 10−5
		Intron-containing	225	27.4 ± 1.336	24
Strain rpb1-1	Half-life (min)	Intronless	4745	18.8 ± 0.143	16	6.5 × 10−8
		Intron-containing	223	16.1 ± 0.463	14

^aP values were calculated using the Mann–Whitney test.