Table 1. Characteristics of the subjects used for oral microbiota analysis and sequencing data.

	Subgroup	Control (n = 25)	SS (n = 25)	P value
Oral drynessa, n (%)		11 (44)	17 (68)	0.154c
Salivary gland hypofunctionb, n (%)		14 (56)	17 (68)	0.561c
Age, mean ± SD	All	50.4 ± 17.1	53.2 ± 10.6	0.484d
	Without dryness	39.6 ± 10.9	51.4 ± 10.7	0.141e
	Dryness	64.2 ± 13.2	54.1 ± 10.8	0.160e
UWSFR, median (range)	All	0.24 (0.02–1.56)	0.10 (0–0.50)	0.125f
	Without dryness	0.37 (0.23–1.56)	0.30 (0.25–0.50)	1.000g
	Dryness	0.05 (0.02–0.10)	0.10 (0–0.10)	1.000g
Valid read count, mean ± SD	All	10246 ± 2363	8706 ± 2213	0.021d
	Without dryness	10718 ± 2217	7982 ± 937	0.056e
	Dryness	9645 ± 2511	9047 ± 2565	1.000e
Read length, mean ± SD	All	461 ± 2.9	443 ± 4.1	< 0.0005d
	Without dryness	461 ± 1.9	445 ± 2.3	< 0.0005e
	Dryness	461 ± 3.9	442 ± 4.5	< 0.0005e
Goods Lib. Coverage, mean ± SD	All	0.992±0.003	0.991±0.003	0.176d
	Without dryness	0.992±0.003	0.989±0.003	0.047e
	Dryness	0.992±0.003	0.992±0.002	0.878e

SS: Sjögren’s syndrome; UWSFR: unstimulated whole salivary flow rate

^a, UWSFR ≤ 0.1 ml/min;

^b, UWSFR < 0.25 ml/min;

^c, by Fisher’s exact test;

^d, by t-test;

^e, by ANOVA with Bonferroni post hoc test;

^f, by Mann-Whitney test;

^g, by Kruskal-Wallis with Bonferroni post hoc test