TABLE 1.
MicroRNAs regulated by TGF-β/Smad signaling in renal fibrosis.
| Micro RNA | Target genes/Mechanisms |
| Antifibrotic | |
| miR-15b | TβR1 |
| miR-19b | TβR2 |
| miR-26a | Smad4 |
| miR-29 | TGF-β1/2, Col, MMP, Fos, Adams, HDAC4 |
| miR-30 | TGF-β2, Snail |
| miR-101 | TβR1 |
| miR-130b | TβR1 |
| miR-let-7 | TβR1 |
| Antifibrotic or profibrotic | |
| miR-145 | TβR2, latent TGF-β1, KLF4 |
| miR-192 | P53, Zeb1/2E-cadherin |
| miR-200 | TGF-β2, Zeb1/2E-cadherin |
| Profibrotic | |
| miR-17-5p | Smad7 |
| miR-216a | PTEN |
| miR-217 | PTEN |
| miR-377 | SIRT1 |
| miR-382 | HSPD1, SOD2 |
| miR-491-5p | Par-3 |
| Profibrotic and pro-inflammatory | |
| miR-21 | Smad7, PPARα, PTEN, ERK/MAPK, Spry1 |