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. Author manuscript; available in PMC: 2020 Jun 18.
Published in final edited form as: Sci Transl Med. 2019 Dec 18;11(523):eaay2736. doi: 10.1126/scitranslmed.aay2736

Fig. 7. Pathology scores are lower in fetuses from vaccinated versus control dams.

Fig. 7.

(A) Fetal brain (13–20 sections/animal), placenta (1–2 sections/animal), amnion (1–2 sections/animal) and eye (1 section/animal) were evaluated blindly by 2 pathologists and were assigned a score from 0 to 4 based on severity (see tables S2–3 for more details, including the scoring system). nd indicates not done (due to fetal death with autolysis). * indicates Vax348-F that was removed via hysterotomy on GD 148 due to fetal distress. (B) Comparison of fetal brain pathology scores between control (n=10) and vaccine group (n=12) fetuses (P = 0.10; one-sided Mann-Whitney). Horizontal lines represent median value. Vax-348-F (with placental insufficiency/brain hypoxia) is indicated by an arrow. (C) Comparison of the duration of maternal viremia with pathology score in the 10 control fetuses that survived to the end of gestation (P = 0.04; one-tailed Mann-Whitney). . (D) Comparison of total fetal pathology score between vaccinated dams with or without viremia; P =0.37 and 0.16 (one-tailed Mann-Whitney), with and without inclusion of Vax-348-F with placental insufficiency, respectively. (E) Duration of maternal viremia in the 13 vaccinated dams in comparison to fetal pathology score (P = 0.46; one-tailed Mann-Whitney).