Table 1.
Comparison of characteristics between male and female workers*.
| Characteristic | Workers in swine operations | |
|---|---|---|
| Males (N = 240) | Females (N = 134) | |
| Age, year | 36.2 ±11.9 | 34.9 ± 10.7 |
| Weight, kg | 88.1 ± 16.6 | 75.5 ± 15.0# |
| Height, cm | 170.8 ± 6.1 | 164.4 ± 5.8# |
| Smoking Status, N (%) | ||
| Current smoker | 73 (30.4) | 44 (32.8) |
| Former smoker | 68 (28.3) | 33 (24.6) |
| Non smoker | 99 (41.3) | 57 (42.5) |
| Atopy, N (%) | ||
| Yes | 86 (38.7) | 37 (29.4) |
| No | 136 (61.3) | 89 (70.6) |
| Lung function | ||
| Observed | ||
| FEV1, L | 4.1 ± 0.7 | 3.1 ± 0.6# |
| FVC, L | 5.3 ± 0.8 | 3.9 ± 0.6# |
| FEV1/FVC, % | 77.8 ± 6.6 | 78.0 ± 6.2# |
| FEF25%−75%, L | 3.8 ± 1.2 | 3.2 ± 1.0# |
| TLR1, N (%) | ||
| RS5743551 | ||
| AA | 78 (44.6) | 58 (56.3) |
| AG | 78 (44.6) | 38 (36.9) |
| GG | 19 (10.9) | 7 (6.8) |
| MAF(G) | 116 (33.1) | 52 (25.2) |
| TLR2, N (%) | ||
| RS4696480 | ||
| AA | 40 (22.9) | 28 (27.2) |
| AT | 89 (50.9) | 55 (53.4) |
| TT | 46 (26.3) | 20 (19.4) |
| MAF(A) | 181 (51.7) | 95 (46.1) |
| RS5743708 | ||
| AG | 9 (5.2) | 9 (8.8) |
| GG | 164 (94.8) | 93 (91.2) |
| MAF(A) | 9 (2.6) | 9 (4.4) |
| LD (D′) | 0.5523 | |
| TLR3, N (%) | ||
| RS3775291 | ||
| AA | 27 (15.3) | 9 (8.8) |
| AG | 72 (40.9) | 45 (44.1) |
| GG | 77 (43.8) | 48 (47.1) |
| MAF(A) | 126 (35.8) | 63 (30.9) |
| TLR4, N (%) | ||
| RS4986790 | ||
| AA | 150 (86.7) | 88 (88.0) |
| AG | 23 (13.3) | 12 (12.0) |
| MAF(G) | 23 (6.7) | 12 (6.0) |
| RS4986791 | ||
| CT | 20 (11.6) | 13 (13.0) |
| TT | 153 (88.4) | 87 (87.0) |
| MAF(C) | 20 (5.8) | 13 (6.5) |
| LD (D′) | 0.9652 | |
| TLR5, N (%) | ||
| RS5744168 | ||
| AG | 9 (5.1) | 16 (15.8)# |
| GG | 169 (94.9) | 85 (84.2) |
| MAF(A) | 9 (2.5) | 16 (7.9) |
| TLR6, N (%) | ||
| RS5743810 | ||
| AA | 21 (12.0) | 17 (16.7) |
| AG | 80 (45.7) | 43 (42.2) |
| GG | 74 (42.3) | 42 (41.2) |
| MAF(A) | 122 (34.9) | 77 (37.8) |
| TLR9, N (%) | ||
| RS187084 | ||
| AA | 66 (37.7) | 27 (26.5) |
| AG | 76 (43.4) | 54 (52.9) |
| GG | 33 (18.9) | 21 (20.6) |
| MAF(G) | 142 (40.6) | 96 (47.1) |
| TLR10, N (%) | ||
| RS4129009 | ||
| AA | 97 (55.4) | 74 (72.6)# |
| AG | 64 (36.6) | 23 (22.6) |
| GG | 14 (8.0) | 5 (4.9) |
| MAF(G) | 92 (26.3) | 33 (16.2) |
*:
Data are presented as mean ±SD unless otherwise indicated.
The polymorphisms of rs2302267 in the TLR7 gene were excluded from our study due to the violation of the HWE in female workers.
The polymorphism of rs5743708 in the TLR2 gene and the polymorphisms of rs5744168 in the TLR5 gene were excluded due to their minor allele frequency (MAF) less than 5%.
#
Significant from males p < 0.05