Table 2.
Gender-specific effects of polymorphisms of the TLR genes on lung function in the workers in multivariate analysis*.
| Gene | Lung function | Male workers | Female workers | ||||
|---|---|---|---|---|---|---|---|
| Polymorphism mean (SE) | Wild-type mean (SE) | Difference (SE) | Polymorphism mean (SE) | Wild-type mean (SE) | Difference (SE) | ||
| TLR1 | |||||||
| RS5743551 | FEV1, L | 3.84 (0.06) | 3.86 (0.06) | −0.03 (0.07)d | 3.22 (0.07) | 3.22 (0.07) | −0.01 (0.07)d |
| FVC, L | 4.92 (0.07) | 4.98 (0.09) | −0.06 (0.09)d | 4.17 (0.09) | 4.24 (0.08) | −0.07 (0.09)d | |
| FEV1/FVC, % | 78.35 (1.55) | 77.67 (0.66) | 0.68 (1.55)r | 76.82 (0.99) | 75.76 (0.94) | 1.06(0.98)d | |
| FEF25%–75%, L | 3.70 (0.27) | 3.62 (0.11) | 0.09 (0.27)r | 2.84 (0.28) | 2.94 (0.13) | −0.10 (0.29)r | |
| TLR2 | |||||||
| RS4696480 | FEV1, L | 3.93 (0.08) | 3.81 (0.05) | 0.12 (0.09)r | 3.39 (0.08) | 3.14 (0.06) | 0.25 (0.08)r‡ |
| FVC, L | 5.01 (0.09) | 4.92 (0.06) | 0.08 (0.10)r | 4.38 (0.09) | 4.11 (0.08) | 0.27 (0.09)r‡ | |
| FEV1/FVC, % | 78.41 (1.06) | 77.25 (0.72) | 1.16 (1.19)r | 76.82 (1.12) | 75.92 (0.91) | 0.90 (1.13)r | |
| FEF25%–75%, L | 3.88 (0.18) | 3.48 (0.12) | 0.40 (0.21)r | 3.16 (0.16) | 2.82 (0.13) | 0.34 (0.16)r‡ | |
| TLR3 | |||||||
| RS3775291 | FEV1, L | 4.02 (0.09) | 3.80 (0.05) | 0.21 (0.10)r† | 3.15 (0.13) | 3.26 (0.06) | −0.11 (0.12)r |
| FVC, L | 5.16 (0.12) | 4.89 (0.06) | 0.27 (0.12)r† | 4.20 (0.15) | 4.23 (0.08) | −0.04 (0.15)r | |
| FEV1/FVC, % | 77.31 (0.75) | 78.20 (0.87) | −0.89 (0.99)d | 74.91 (1.75) | 76.64 (0.87) | −1.73 (1.71)r | |
| FEF25%–75%, L | 3.84 (0.22) | 3.56 (0.12) | 0.28 (0.24)r | 2.66 (0.25) | 3.02 (0.13) | −0.36 (0.25)r | |
| TLR4 | |||||||
| RS4986790 | FEV1, L | 3.91 (0.11) | 3.87 (0.05) | 0.04 (0.12)d | 3.17 (0.11) | 3.29 (0.07) | −0.12 (0.12)d |
| FVC, L | 5.13 (0.14) | 4.97 (0.06) | 0.16 (0.14)d | 4.05 (0.12) | 4.23 (0.08) | −0.18 (0.13)d | |
| FEV1/FVC, % | 76.31 (1.44) | 77.82 (0.66) | −1.50 (1.45)d | 77.65 (1.39) | 77.59 (0.92) | 0.06 (1.51)d | |
| FEF25%–75%, L | 3.58 (0.25) | 3.65 (0.11) | −0.06 (0.25)d | 3.01 (0.22) | 3.19 (0.14) | −0.18 (0.23)d | |
| TLR6 | |||||||
| RS5743810 | FEV1, L | 4.03 (0.11) | 3.82 (0.05) | 0.21 (0.11)r | 3.23 (0.07) | 3.21 (0.08) | 0.02 (0.07)d |
| FVC, L | 5.02 (0.14) | 4.93 (0.06) | 0.09 (0.14)r | 4.23 (0.08) | 4.18 (0.09) | 0.05 (0.09)d | |
| FEV1/FVC, % | 80.40 (1.49) | 77.34 (0.66) | 3.06 (1.50)r† | 77.34 (1.37) | 76.01 (0.86) | 1.33 (1.29)r | |
| FEF25%–75%, L | 4.14 (0.26) | 3.55 (0.11) | 0.59 (0.26)r† | 3.07 (0.20) | 2.91 (0.13) | 0.16 (0.19)r | |
| TLR9 | |||||||
| RS187084 | FEV1, L | 3.74 (0.09) | 3.88 (0.05) | −0.14 (0.09)r | 3.25 (0.09) | 3.21 (0.07) | 0.03 (0.09)r |
| FVC, L | 4.68 (0.10) | 5.02 (0.06) | −0.34 (0.11)r‡ | 4.30 (0.11) | 4.17 (0.08) | 0.13 (0.10)r | |
| FEV1/FVC, % | 79.59 (1.16) | 77.09 (0.69) | 2.51 (1.24)r† | 75.01 (1.20) | 76.67 (0.89) | −1.66 (1.19)r | |
| FEF25%–75%, L | 3.79 (0.20) | 3.56 (0.12) | 0.24 (0.22)r | 2.98 (0.13) | 2.82 (0.17) | 0.16 (0.16)d | |
| TLR10 | |||||||
| RS4129009 | FEV1, L | 3.94 (0.13) | 3.84 (0.05) | 0.11 (0.13)r | 3.18 (0.17) | 3.23 (0.06) | −0.04 (0.17)r |
| FVC, L | 5.04 (0.16) | 4.94 (0.06) | 0.10 (0.16)r | 4.13 (0.20) | 4.21 (0.08) | −0.08 (0.20)r | |
| FEV1/FVC, % | 77.83 (0.83) | 77.51 (0.79) | 0.32 (0.98)d | 76.55 (1.17) | 76.11 (0.89) | 0.45 (1.09)d | |
| FEF25%–75%, L | 3.57 (0.14) | 3.65 (0.14) | −0.09 (0.17)d | 2.76 (0.34) | 2.95 (0.13) | −0.19 (0.34)r | |
*:
Only those SNPs which follow HWE and are common variances (MAF>5.0%) were selected into the multivariate models adjusting for age, height, weight, and smoking habit.
†:
Significant at α = 0.05 level.
‡:
Significant after adjusting for multiple comparison at α = 0.007 (0.05/7).
d:
(dominant inheritance has the best-fitted model).
r:
(recessive inheritance has the best-fitted model).