Table 3.
Modification effects of age on the female-specific associations between the TLR2-rs4696480 polymorphisms and lung function (N = 103)*.
| TLR2-RS4696480 polymorphisms | |||
|---|---|---|---|
| Polymorphism mean (STE) | Wild-type mean (STE) | Comparison† difference (STE) | |
| Female workers aged <45.8 years | |||
| (N = 83, Mean = 31, range:18–45) | |||
| Lung function | |||
| FEV1, L | 3.68 (0.09) | 3.39 (0.08) | 0.30 (0.09)‡ |
| FVC, L | 4.59 (0.09) | 4.28 (0.08) | 0.30 (0.10)‡ |
| Female workers aged ≥45.8 years | |||
| (N = 20, Mean = 50 Range:46–57) | |||
| FEV1, L | 2.66 (0.25) | 2.56 (0.15) | 0.11 (0.27) |
| FVC, L | 3.76 (0.34) | 3.79 (0.21) | −0.03 (0.38) |
*:
The cut-point of the age variable at 45.8 years was provided by the decision tree models.
†:
p values were from multivariate models adjusting for height, weight and smoking habit.
‡:
Significant after adjusting for multiple comparison at α = 0.007 (0.05/7).