FIG 5.
In vivo bioluminescence imaging comparing N. caninum and T. gondii acute infections in MCP (CCL2) knockout (MCP−/−) or WT C57BL/6 mice. MCP−/− mice (n = 3 per parasite species) and C57BL/6 (control) mice (n = 3 per parasite species) were infected with 106 tachyzoites of either N. caninum or T. gondii. (A) Survival of mice throughout acute infection. (B) Parasite burden of Nc1:Luc infection in either C57BL/6 or MCP−/− mice. Data were log transformed, and two-way repeated-measures ANOVA (alpha value of 0.05) with Dunnett’s multiple-comparison test was performed. No statistically significant differences were found in the MCP−/− mouse comparison for Nc1 infection. (C) TgS1T:Luc infections in C57BL/6 or MCP−/− mice. Data were log transformed, and two-way repeated-measures ANOVA with Dunnett’s multiple-comparison test was performed. No statistically significant differences were found in the MCP−/− mouse comparison for TgS1T infection.