TABLE 3.

Haplotype association analysis for ARNT2 and CX3CR1 SNPs^a

Gene	Nucleotide in:							Freq	OR (95%CI) of discovery population (n = 424)	P
	rs1374213	rs12439281	rs7931529	rs9823718	rs9862876	rs9868689	rs12107527
ARNT2b	A	G						0.424	1.00
	G	G						0.387	1.13 (0.73–1.76)	0.58
	A	T						0.120	0.32 (0.08–1.28)	0.11
	G	T						0.070	2.62 (1.25–5.47)	0.011
CX3CR1c			G	C	C	G	G	0.4645	1.00
			G	C	C	G	A	0.1874	0.55 (0.31–1.00)	0.050
			G	C	G	A	A	0.1056	1.46 (0.79–2.71)	0.23
			G	C	G	A	G	0.0602	0.37 (0.13–1.09)	0.073
			A	G	C	G	G	0.0563	3.56 (1.78–7.13)	0.0004
			G	C	G	G	G	0.0497	0.49 (0.17–1.41)	0.19
			G	G	C	G	G	0.0325	1.88 (0.77–4.60)	0.17
			A	G	C	G	A	0.0176	0.29 (0.01–13.5)	0.52

^aNucleotides that are bold and underlined represent those alleles that were significantly associated with IA risk in the single SNP analysis. Association estimates were adjusted for age, sex, and country of origin. The minimum haplotype frequency (Freq) was set at 0.01. P values that were ≤0.05 are in bold.

^bThe global haplotype association P value was 0.014.

^cThe global haplotype association P value was 0.00019.